Pyrimidine Biosynthesis in Human Malaria Parasite Plasmodium falciparum: Biochemical and Molecular Characterization of Orotate
Phosphoribosyltransferase and Orotidylate Decarboxylase
The specific objective of this project is to identify unique characteristics of the enzymes OPRTase and ODCase of the pyrimidine biosynthetic pathway of P. falciparum using biochemical and molecular techniques. This will be the first time to validate the