Thus far, membrane insertion behavior, oligomerisation and structural information of the functional state of the membrane-associated Cry larvicidal proteins are still not fully described. This project will attempt further: (1) To characterise structurally the functional oligomeric form of the Cry4Ba toxin in association with the lipid membranes. (2) To investigate the conformational changes of the Cry4Ba toxin: the transition from the oligomeric prepore to the membrane-inserted pore form
