Regulation of MyD88-dependent and -independent signaling pathway by signal regulatory
protein-? in Burkholderia pseudomallei infection
Regulation of MyD88-dependent and -independent signaling pathway by signal regulatory
protein-? in Burkholderia pseudomallei infection
Regulation of MyD88-dependent and -independent signaling pathway by signal regulatory protein-? in Burkholderia pseudomallei infection
1. To investigate comparatively the expression trend of SIRP-? gene and protein in the mouse macrophage cell line (RAW 264.7) infected with B. pseudomallei, its LPS mutant (SRM 117)
2. To investigate the regulatory mechanisms that control, if any differential SIRP-? gene and protein expression in the context of B. pseudomallei and its LPS mutant infection.
3. To investigate the significant role of SIRP-? in controlling intracellular survival of B. pseudomallei and its LPS mutant in mouse macrophage.
4. To investigate, if any significant involvement of SIRP-? expression in the regulation of MyD88-dependent and -independent pathway.