1) Determine baseline host and viral factors, and kinetics of HBsAg/HBeAg levels during therapy in predicting treatment response of patients with chronic HBV infection
2) Determine host genetic variations associated with clearance of HBV infection
3) Determine host and viral factors associated with the development of cirrhosis and HCC
4) Determine the role of cccDNA in HBV-related HCC and occult HBV infection
5) Determine molecular epidemiology and natural history of chronic HCV genotype 6 by comparison to those of genotype 1 and 3
6) Determine host genetic variations and viral factors associated with treatment response in patients with chronic HCV infection
