Searching for bioactive alkaloids: Applications of oxazolones to the synthesis of diverse heterocyclic scaffolds and screening of Lycopodium alkaloids from Thai club mosses
1. To study the reaction conditions of copper-mediated and microwave-assisted C-O and C-N bond formation from oxazolone derivatives
2. To apply the developed methodology of copper-mediated and microwave-assisted C-O and C-N bond formation to synthesize 3-amidocoumarin, azanovobiocin, and indol-2-carboxylic acid derivatives
3. To study the biological activity of our synthetic compounds, 3-amidocoumarin, azanovobiocin, and indol-2-carboxylic acid derivatives
4. To study the acid-catalyzed isoquinoline cyclization from 2-amidocinnamic acid derivatives
5. To synthesize 1-arylisoquinoline-3-carboxamides and b-carboline derivatives using the optimized acid-catalyzed isoquinoline cyclization condition
6. To synthesize two Clausena alkaloids, z-clausenamide and balasubramide
7. To screen for biologically active Lycopodium alkaloids from Indo-China club mosses from Thailand and neighboring countries
8. To isolate and purify and search for new skeletons of the Lycopodium alkaloids using spectroscopic techniques and computational methods for NMR calculations
9. To investigate the semi-synthesis of Lycopodium alkaloid analogs from the biologically active Lycopodium alkaloids
10. To evaluate biological activities of natural and semi-synthetic Lycopodium alkaloids for potent inhibition of acetylcholinesterase enzyme and investigate anti-proliferation and anti-invasion effects of AChE inhibitors
