1. To discover new anti-AD/T2DM drug lead compounds through a combination of library screening, pharmacologic mechanism investigation and structure-based optimization of lead compounds by targeting the Thai-plant and fungal resources based compound library.
2. To study the binding mechanism of active compounds to AD and T2DM targets using theoretical techniques, design and synthesize the selected inhibitors.
3. To develop new bioassays (both targeted and phenotypic assays) for discovering lead molecules for application in the treatment of AD and T2DM in Thailand