1 To elucidate the mechanism of genome-wide hypomethylation in cellular senescence
2 To measure the genome-wide methylation by using SS1 DNA methyl transferase and methylation in repetitive elements by modified COBRA PCR in cellular senescence
3 To study the association between genome-wide methylation level and cellular senescence and aging
4 To study the growth rate, morphology and phenotypic and functional changes in cellular senescence and aging
