2.1 To investigate the interaction and the possible roles of prostacyclin analogue in promoting the angiogenesis of human dental pulp cells, particularly via the up-regulation of proliferating factors; VEGF,FGF-2 and PDGF.
2.2 To study the effect of prostacyclin analogue on promoting dental pulp healing in animal by establishing the application of prostacyclin delivered to the tooth injured model and further study the possibility of applying prostacyclin as an adjuvant for drug delivery treatment in clinical situation.
