1. To investigate the structural concept for rational design of bi-functional inhibitors against both of DHQ dehydratase and shikimate dehydrogenase through HQSAR, CoMSIA and MD simulation approaches
2. To design bi-functional inhibitors of DHQ dehydratase and shikimate dehydrogenase on the basis of the obtained structural concept
3. To identify bi-functional inhibitors from commercial compound databases using virtual screening