Aim #1 To investigate the effect of iron overload condition on body weight, blood pressure and the progression of cardiac dysfunction in normal and thalassemic mice under iron overload condition.
Aim #2 To investigate the effect of pharmacological interventions on biochemical parameter and cardiac function in normal and thalassemic mice under iron overload condition.
Aim #3 To investigate the effect of pharmacological interventions on isolated cardiomyocytes intracellular Ca2+ transient and cardiac calcium cycling proteins expression innormal and thalassemic mice under iron overload condition.
