To experimentally verify the interaction binding modes between yeast TFs and nucleosomes, as computationally predicted.
To establish a platform for system-wide transcriptional and binding profiles of DNA-binding proteins, including TFs and nucleosomes, using RNA-seq and ChIP-seq, respectively.
To further develop and refine the analytic pipeline for next-generation sequencing (NGS) data from publicly available applications, which will also be adapted and implemented on other genomes in the future.
