Effect of Sildenafil Citrate and the Combined Nitric Oxide Donor and Sildenafil on the Defibrillation Efficacy and the Arrhythmogenesis of Ventricular Fibrillation
To determined the effect of sildenafil citrate and the combined nitric oxide donor and sildenafil on the defibrillation efficacy as well as their effects on the arrhythmogenesis of VF. The following hypotheses will be tested.
Hypothesis #1:Acute sildenafil citrate administration significantly decreases the defibrillation efficacy.
Hypothesis #2: Acute administration of combined sildenafil citrate and nitric oxide donor significantly decreases the defibrillation efficacy more than the administration of sildenafil alone.
Hypothesis #3: Acute sildenafil citrate administration causes the heart to be vulnerable to VF.
Hypothesis #4: Acute administration of combined sildenafil citrate and nitric oxide donor causes the heart to be more vulnerable to VF than the administration of sildenafil alone.
