1. To identify quantitative and qualitative changes of a set of proteins (proteome) in renal tubular cells in response to CaOx monohydrate (COM) crystal adhesion.
2. To identify quantitative and qualitative changes of a set of proteins (proteome) in renal tubular cells in response to CaOx dihydrate (COD) crystal adhesion.
3. To determine differential cellular responses to crystal adhesion with different types of CaOx crystals - COM vs. COD.