Evolution of Duffy antigen receptor for chemokines (DARC) of Macaca nemestrina and M. fascicularis and susceptibility to Plasmodium vivax-related malaria (P. knowlesi and P. cynomolgi)
-To explore the diversity in the DARC locus of M. nemestrina and M. fascicularis populations in southern Thailand.
-To determine which SNP at the promoter (FY cis-regulatory region) of the DARC gene governs Duffy antigen expression in macaques.
-To investigate the extent of sequence diversity and the pattern of selection at the DBP homologues in P. knowlesi and P. cynomolgi.
-To correlate the SNP at the FY cis-regulatory region in DARC homoloques and P. vivax- related malaria susceptibility in macaque populations in Thailand.
