? To elucidate the physicochemical properties of hemoglobin variants and its small-molecule effectors through structure-function relationship and structure-activity relationship studies.
? To understand the underlying logic governing hemoglobin function (e.g. redox activity, oxygen binding, etc.) through the use of molecular modeling, molecular dynamics and molecular docking approaches.
? To employ the mentioned computational approaches in guiding the engineering of hemoglobin variants possessing the desired properties (e.g. lowered redox reactivity and optimal oxygen binding properties).
? To design and produce haptoglobin mimics that would neutralize the deleterious effects of hemoglobin.
