The primary objective of the study is to compare the incidence of perioperative myocardial injury between short-term bisoprolol treatment and placebo. The secondary objective is to compare the incidence of a composite of all-cause death, nonfatal MI and nonfatal stroke at 30 days after surgery between the 2 treatment arms. The tertiary objective is to study the effect of short-term bisoprolol on biomarkers (C-reactive protein, plasma malondialdehyde, and N-terminal proB-type natriuretic peptide, 8-isoprostaglandin F2 alpha (oxidative stress), interleukin (IL)-6 and TNF alpha).
