Systematic Analysis of Drugs, Clinical Candidates and Development Compounds: Understanding the Causes of Drug Attrition and Derivation of Improved Guidelines for Use in Pre-clinical Development
Extract a comprehensive dataset of drugs and development compounds from literature databases containing biochemical, ADMET and physico-chemical parameters.
Evaluate historical drugs and failed compounds to determine which ADMET/Potency parameters, appear to play the most important role in defining drug space (i.e. what redundancy is their given their inter-correlation with physico-chemical parameters).
Define optimal guidelines values for each parameter to aid future development strategies. i.e. What level do we really need for each parameter?
Analyze SAR trends to discern key factors controlling both ADMET parameters and overall attrition
