The optimization of in vitro test for the diagnosis of drug-induced severe cutaneous adverse reactions in Thailand
หัวหน้าโครงการ
:
เจตทะนง แกล้วสงคราม
ทีมวิจัย
:
เจตทะนง แกล้วสงคราม
หัวหน้าโครงการ
วันที่เริ่มโครงการ
:
1 ก.ค. 2558
วัตถุประสงค์
:
1) To analyze the alteration of in vitro immunological responses after stimulating peripheral blood mononuclear cells with drugs commonly caused severe non-immediate hypersensitivity reactions in Thailand compared to baseline in drug allergic subjects
2) To identify potential in vitro parameters and enhance immune responses after stimulating peripheral blood mononuclear cells with the culprit drugs for distinguishing the differences between drug tolerant and drug allergic subjects
3) To explore the appropriate immunological markers and optimization of in vitro techniques to identify the culprit drug in patients with drug-induced severe non-immediate reactions and to guide the prescription of safe alternative drug
