Molecular and Physiological Characterization of Family of Organic Peroxide Sensor and Transcription Regulators and How The System Response to Changes in The Environment
The major goal of the research is to understanding the function of these OhrR homologues and the genes regulated. Most of the genes regulated by OhrR such as ohr, glutathione S-transferase and chloroperoxidase have not been characterized and their biochemical and physiological functions are unknown. The knowledge will help elucidate the physiological function of these proteins and more importantly in general how bacteria can sense changes in the environment and send appropriate signals to activate or repress expression of genes in response to the stress. This is the central issue on how living organisms recognize changes in the environment and the signal transduction processes.
