1. To analyze the quantitative bleeding symptoms, complete laboratory investigations, molecular genetic study among patients with von Willebrand disease.
2. To identify Thai children with thromboembolism, search for the congenital and acquired risk factors and create computerized program for entering the long-term follow-up medical records.
3. To initiate a multicenter study of patients with von Willebrand disease and children with thrombosis.
4. To study the association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirement in Thai patients.
5. To study the pathophysiological changes of vascular environment leading to dengue shock syndrome in dengue infected patients.
