1. To identify, characterize and culture the neural stem cells obtained from different brain regions (SVZ, SGZ and midbrain)
2. To investigate and elucidate the mechanisms of the illicit substances such as amphetamines affecting neurogenesis and early brain development
3. To investigate and elucidate the mechanisms of amphetamine, trigger cell death and induce age-related neurodegeneration
4. To investigate certain environmental factors, such as stress affecting neurogenesis
5. To investigate and elucidate whether melatonin can enhance neurogenesis and restore of surviving neurons in drug addiction and stress exposure
6. To identify the roles of neuroprotective agents especially of melatonin and natural growth factors (BDNF) in developing and adult nerve cells, and the pharmacological potential of the factors to prevent death of the neurons, to maintain their functions and to enhance neurogenesis
7. To investigate the possibility of neural stem cells transplanted in damage brain and in neurodegeneration
