To investigate whether obese-insulin resistant rats with cognitive decline, induced by 12-week HFD consumption, develop gut dysbiosis, increased gut microbederived metabolite (trimethylamine N-oxide (TMAO)), gut inflammation, systemic inflammation, and brain inflammation and microglia/astrocyte hyperactivity
To investigate whether obese-insulin resistant rats with cognitive decline induced by 12-week HFD consumption, have shortening telomere length, and increased brain AD pathological condition.
To study the effects of either probiotic or prebiotic or synbiotics on insulin sensitivity and inflammation in both circulation and brain of obese-insulin resistant rats.
To study the effects of either probiotics or prebiotics or synbiotics on brain function of obese-insulin resistant rats.
To study the effect of NAC on peripheral insulin sensitivity, circulating inflammation and brain functions in obese-insulin resistant rats.
To investigate the association among gut dysbiosis, TMAO level, the metabolic parameters and cognitive function in metabolic syndrome patients.
