1. To study the subcellular distribution of steroidogenic enzymes, ERs and synaptic proteins in aged hippocampus 2. To study the effects of aged microglia on the biosynthesis of estrogen and its modulatory functions on synaptic plasticity in aged hippocampal neuron culture. 3. To study the signaling mechanisms of aged microglia-derived cytokines mediate estrogen biosynthesis in aged hippocampal neuron culture.
