2.1 To develop an efficient and general routh to cyclic peptides via an on-resin tandem Fmoc-deprotection-macrocyclisation approach employing the sulfonamide safety-catch linker 2.2 To apply the methodology developed to access constrained cyclic peptides and cyclic peptide natural products of different ring sizes 2.3 To submit the synthesised cyclic peptides to bioactivity screenings and/or further structure-activity or mechanism of action studies where appropriate
